Endocrine Abstracts

Introduction: Programmed death-1 (PD-1) is one of the most important inhibitory co-receptors. Studies show that the PD-1/PD-L1 pathway regulates the induction and maintenance of peripheral tolerance and protects tissues from autoimmune attack in physiological conditions. Several studies have shown association of PD-1/PD-L1 pathway with several autoimmune diseases although, to date, no such studies have been performed for Graves’ disease (GD).Aims: T...

Introduction: Glucocorticoids (GC) are used for immunosuppression in many clinical conditions. Pre-clinical and early clinical studies suggested that the induction of regulatory T (Treg) cells contributes to the immunosupressive effects of GCs. However, in the hitherto reported clinical studies only patients with ongoing autoimmune diseases were included. Our goal, therefore, was to determine the influence of exogenous GCs in vivo in immunocompetent subjects and mice.</...

Introduction: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as type II enteropathy-associated T-cell lymphoma, is a rare and aggressive subtype of lymphoma of the gastrointestinal track typically noted in Asian or Hispanic populations. Adrenal involvement as part of MEITL is extremely rare. Herein we present a patient of Greek origin with MEITL and bilateral adrenal metastases.Case Presentation: A 74-year-old man presente...

Background: Prevalence of hypogonadism is high (30%) in men with HIV. In these patients T treatment (TT) is currently used mainly to counteract wasting syndrome and/or HIV-related lipodystrophy, irrespective of patients’ serum T. However, its effect and safety in HIV-infected men is still not completely known.Aim: To investigate both beneficial and adverse effects related to TT in HIV-infected men using a meta-analytic approach.<p class="abstext...

Introduction: Central hypothyroidism is rare, estimated to occur in 1:20,000 to 1:80,000 in the general population. Pituitary mass lesions and adverse effects of their treatment are the most common causes of central hypothyroidism. In recent years, the incidence of pituitary hormonal deficiencies as adverse effects of novel molecular targeting anticancer drugs has risen sharply. Especially checkpoint inhibitors are associated with partial or complete hypopituitarism. In this r...

Background and aims: Bexarotene is the first retinoid receptor X (RXR)-selective agonist approved for cutaneous T-cell lymphoma in patients resistant to at least one previus systemic treatment. However, it produces often two endocrine-metabolic alterations: central hypothyroidism and dyslipidemia. We assessed, in a group of patients with Mycosis Fungoide or Sezary syndrome treated with bexarotene, the endocrine-metabolic side effects.Patients and methods...

Objectives: T helper1 (Th1) cells were determined to have important roles in the development of type 2 diabetes (T2D). We aimed to investigate relationship between Th1 cytokines (IFN γ, IL-2 and TNF-α) and T2D.Material and methods: The study included 32 newly diagnosed type 2 diabetic patients (T2DPs) who had not begun to take antidiabetic agents except from insulin and 30 healthy subjects (CG) who did not have glucose intoerance (fasting or af...

BackgroundCytochrome P450 oxidoreductase (POR) deficiency is an autosomal recessive steroidogenesis disorder similar to combined deficiencies of 17a-hydroxylase, 17, 20-lyase, 21-hydroxylase. POR deficiency (PORD) is a very rare type of congenital adrenal hyperplasia(CAH) characterized by sexual development disorders and skeletal anomalies. We present a case that was evaluated with a prediagnosis of nonclassical CAH and was found to have a heterozygo...

T Yoshimura, Nagoya University, Nagoya, Japan AbstractProf. Takashi Yoshimura graduated from the Graduate School of Agriculture, Nagoya University in 1996. In 1995 he was awarded the JSPS Research Fellowship for young scientists and between 1996 and 1999 he worked as a Research Associate at the School of Agriculture, Nagoya University. At the same institution he was Assistant professor until 2005 and later became the ...

Metabolic syndrome is a cascade of metabolic diseases starting with obesity and progressing to atherosclerosis and is often fatal because of serious cardiovascular problems such as heart/brain infarction and hemorrhage. Accumulating evidence has revealed a critical involvement of inflammatory responses triggered by lesional macrophages in its pathogenesis. Importantly, we found that macrophages are associated with the progression of these diseases not only in the induction of ...